Final Report : Acquisition of a Thermophoresis Instrument for Molecular Association Thermodynamic Studies

Number of Papers published in peer-reviewed journals: Number of Papers published in non peer-reviewed journals: Final Report: Acquisition of a Thermophoresis Instrument for Molecular Association Thermodynamic Studies Report Title Funding from the Department of the Army, with matching funds from the University of California, Riverside, was used for the acquisition of a microscale thermophoresis instrument. This instrument is used to quantify biomolecular interactions by measuring binding affinities. We provide examples from the use of thermophoresis measurements in research projects. (a) Papers published in peer-reviewed journals (N/A for none) Enter List of papers submitted or published that acknowledge ARO support from the start of the project to the date of this printing. List the papers, including journal references, in the following categories: (b) Papers published in non-peer-reviewed journals (N/A for none) Paper presented at the following meeting: 1/15/2015, “Development of low-molecular mass biomarkers of complement activation and testing in a macular degeneration model”, 7th Annual Conference of the Arnold and Mabel Beckman Initiative for Macular Research, Beckman Center of the National Academies of Sciences and Engineering, Irvine, CA, January 15-17, 2015. We have written the following manuscript draft that is expected to be submitted within a month, after we complete the experimental work (attached in the Scientific Progress section): Gorham RD Jr, Nuñez V, Lin J-H, Rooijakkers SHM, Vullev VI, Morikis D (2015) Discovery of small molecules for fluorescent detection of complement system activa-tion product C3d, Journal of the American Chemical Society, to be submitted. (c) Presentations Received Paper